Objectives: The running away of girls from home is a complex phenomena and one of the most serious social pathology that resulted from multiple factors in familial, psychological and social domain. in fact running away is an important signal that something is seriously wrong in adolescent life. In this research the effective family factors on the running away of girls are identified .Then on this basis with a preventive outlook, scientific and applied tactics are presented .Through different psychological and sociological theories which everyone tells the theorical frame, it was chosen in the case of integrating. Method: The research method of this study is a case control kind. The statistical society is comprised of two groups: The runaway girls (case group) and non- runaway girls (control group). For identifying the effective independent variables, a control group with considering the same socio-economic and family status of runaway girls has been selected. The runaway girl’s sample were selected in using of the available sample of the girls that were inhabited in intervention crisis centers in welfare organization, the girls’ of control group were selected in using of multistage cluster sampling from 19, 16, 20 district of Tehran. After making a list and confirming the validity of questions by professors of social work and sociology, its reliability was confirmed through cronbach alpha coefficient. This information is gathered by systematic interviews. For data analysis and testing the hypothesis chi square (X2) and Cramer’s V was used for describing the study population and from descriptive statistics. Spss software type 11 was used for data’s reductions. Findings: According to statistical analysis of the data, the main result was obtained: About half of runaway girls had run away history and 12 percentages of them had the experience sexual abuse in family. Runaway girls used drugs and alcohol much more than non runaway girls. Also 28% of runaway girls expressed that their family had the history of drug abuse, around 40% divorce and 22 percentages prison experience. Runaway girls were bothered physically and emotionally more than their match group by their family interruption or family members. Disturbing the family conflict and argument between the runaway girls’ family and they were more than the match group. Results: Based on the comparative study and results chi - square ( X2 ) showed there is statistically significant difference between runaway girls and non- runaway girls on rates of parent physical, emotional and sexual Violence toward their girls and parental issues such as, divorce, addiction, prison experience, conflict and arguments .in fact they are the effective main factors for the running away of girls from home .To prevent this social pathology, we need to raise the awareness of parents regarding the appropriate ways to contract with their teenagers. We also need to identify and protect the vulnerable families.