Introduction: The aim of the current research was to investigate determinant of preschool years to school behaviors according to biopsychosocial model of human. Some of variables rooted in delivery period while other variables related to preschool years.

Method: Participant initially were 1428 mothers and their children in postpartum period who respond to CES-D scale in longitudinal research program, also age of their children in the time of delivery and his weight was recorded.3 years later in 1383 mothers respond to questionnaires including Denver Development Screening Test for preschool representative of cognitive and motor development of their children. Performance and behavior of children at 4- Grad in school was measured via children behavior questionnaire, in 1390. The sample was decreased to 1210 persons.

Findings: While maternal depression and poverty jeopardized learning and physical well- being in school years, they unfolding conduct disorder and anxiety. Contrary preschool cognitive and motor development of children increase their learning and physical well-being and diminish conduct disorder and anxiety.

Discussion: according to biopsycho social model, human being were in fluenced by these variables. Social welfare will have signifi cant effect on cognitive and motor development of future generation and omission of poverty can produce better social entity.