Objectives: This research administered with the aim of study the mediator role of attitudes toward welfare development, population needed to welfare, supportive and helping welfare services and welfare policies in relation between empathy and social interest with approaches to social justice in students of Isfahan university. Method: Statistical population of research were the total students of Isfahan university in fall term of 86-87 year. 297 students selected for answer to research questionnaires with using random sampling method. Research questionnaires were: Attitudes toward social welfare with four subscales named welfare development, population needed to welfare, supportive and helping welfare services and welfare policies (total of item were 28), empathy questionnaire with 33 items, social interest questionnaire with 32 items and a questionnaire of approaches to social justice with 9 items. Data analyzed with the use of correlation coefficient and structural equation modeling (SEM). Findings: Analyses of data showed that attitude toward welfare development play mediator role in relation between Social interest with equality approach to social justice. Attitudes toward population needed to welfare play mediator role in relation between social interest with need approach to social justice, attitudes toward supportive and helping welfare services was mediator variable in relation between empathy and equity approach to social justice and finally welfare policies was the mediator variable in relation between empathy and social interest with need approach to social justice. Results: finding of this research revealed that welfare development only play the role of mediator variable for equality approach to justice, and population needed to welfare only play the role of mediator variable for relation between need and social interest. But in relation between equity with empathy, attitudes toward supportive and helping welfare services play the mediator role and welfare policies only play the mediator role in relation between need approach to social justice with empathy and social interest.