Objectires: Totally, programms of substance usage prevention can be divided into two parts of supply and demand reduction. Although numerus activities was done in supply reduction part, today an increase in substance usage is observed among young people. Therfore, determination of factors which can prevent the substance usage are important and necessery. The purpose of this study was to investigate relationship between religiosity and self control with substance abuse.
Method: Sample group was consisted of 386 male students from university of Tehran that were selected by stratified random sampling method. The study instruments were Addiction Acknowledgment Scale, Mac Andrew Alcoholism Scale-R, Low Self- Control Scale- Revised and Religious Attitude scales.
 Findings: The data analysis by Multivariate Analysis of Covariance (MANVCOVA) showed that there was negative correlation between religisity and substance abuse, that is, higher score in religisity accompanies with low probability in substance abuse. Moreover, findings indicated that there was a negative correlation between low self control and substance abuse, in other words, one who has low level of self- control in substance abuse is faced with high risk with higher probablity. 
Discussion: religion can be considered as a preventive factor to substance abuse. Therefore, parents and educatioal centers can decrese the substance use probablity via enhancment of religional belifes.