Objective: The planning for prevention and control of the wives running away from home needs the evidence-based information about its complex bio-psycho-social causality network at the family, husband home and the community levels. This article aims to present a survey on psychosocial factors of running away from home among a sample of Iranian wives. Method: This research is based on a survey on 31 cases and deep interviews with 8 cases in the 9 centers of Welfare Organization and Prisons during 8 months consecutive sampling. Findings: The most run away wives were exposed to domestic violence and a weak network of social support. They felt depression, anxiety, sense of isolation and powerless. They had low access to the valuable resources at the family and they mostly Show extroverted and neurotic personality. Results: The problem of wives running away from home is the consequence of a complex psychosocial causality network and needs more analytical study and strengthening of supportive social organizations and improving the women knowledge about their capabilities and social rights.