The purpose of this article´s presentation is comprehensive, precise and scientific but precis collection of preventive program from substance abuse from beginning to now. Although the science of prevention from substance abuse has a short history, but it is very sensitive because of the importance of the program on one hand and developmental stages based on the evolutionary preventive science on the other hand. In this article the authors try to describe preventive approaches with regarding historical course and explain advantages and disadvantages of these approaches. The presented approaches are information dissemination approach, affective education approach, alternative approach, social influence approach and integrated social influence - competence enhancement approach respectively.