Objectives: Among adolescents and young adults, the phenomenon of running away from the home environment has been associated with a variety of factors such as poverty, violence, discrimination, and limited access to social resources. The long-term consequences are by no means confined to the individual and are likely to have an impact on the society as well. This research uses a causative-experimental model to determine the social and psychologic factors that cause adolescent and young girls to runaway from homes. Methods: Our research included both qualitative studies (6 in-depth interviews and 4 focus group discussions) and a population-based case-control methodology with 281 cases and 250 controls. The cases were drawn from State penitentiaries and rehabilitation centers run by the Welfare Organization. Controls were chosen from the general population of girls in ten different provinces of Iran. Findings: Factors leading girls to run away from home include inequities in access to resources, absence of parents or competent caregivers, divorce, lack of a social support network, abuse and violence, rejection and neglect by the family, inadequate adaptation skills, social dependence, feelings of powerlessness, and lack of established norms of behavior. These social factors have major interactions with such psychologic variables as locus of control and emotion-seeking behavior. Results: Lack of cohesion at community level is associated with a wide range of communicative, normative and distributive abnormalities. Most runaway girls are victims of inequitable access to social and economic resources, a feature closely related to distributive inequalities within the community at large. Poor communication - indicating an absence of supportive relationships- is related to defects in the structure and function of the social milieu and often creates feelings of isolation, hopelessness, and social alienation. Within the person's immediate surroundings, defective social and emotional bonds often lead to a lack of cohesion at the family level. This situation is results from the absence of normative rules or, in other words, the absence of effective social regulation and leads to a state of intense confusion and stress. It must be remembered that poor emotional ties within the family can lead to poor adaptation and coping in the social environment. Hence, defective social integration and reluctance to conform to the social norms are two aspects of the same process their end result is a lack of social commitment. Theoretically, it might be stated that the various problems facing runaway girls are the result of a broad range of social defects at distributive, communicative, and normative levels and these defects in turn reflect poor cohesion within the larger community.