Introduction: Drug abuse is a phenomenon with social, cultural and economic dimensions. This problem has affected on large part of the workforce in many countries. This study aimed to examine the reliability and validity of youth attitude to substance abuse.

Method: using previous  questionnaire’s we designed primary repository of items which then executed on a sample of 510 student’s of universities across the country in 2011-2012 .We selected this students with a multistage sampling. For assessing the validity and reliability of this questionnaire we used of exploratory factor analysis and Cronbach's coefficient were used.

Findings: exploratory factor analysis revealed that 25 items in the model were loaded on 5 factors. These 5 subscales explained about 61 percent of variance of all construct. internal consistency of the total construct was satisfory as Cronbach's alpha coefficient was 0.82.

Discussion: The size and diversity of participants, validity of the results, and the relative shortness of questionnaire, made it a perfect tool for measuring attitudes of young people to drug abuse.