Persons with disabilities as a member of human society always confront to challenge about work and profession. This problems are not necessarily resulted from physical conditions of these persons, but most of the time arise from wrong point of view of society that keep out them of work and activity. In spite of international transitions about this matter in the area of law and sociology, those leading to positive regards for work of persons with disabilities, the exact frame of the right of these persons are uncertain. In this paper, we discuss about the right to work of persons with disabilities in national and international regulations, and set forth the ideal conditions to secure these right for them.