Objectives: In 1380, there were 3,761,000 drug users. They included 1,158,000 addict and 1,390,000 drug abusers. In Iran, around 65 percent of drug dependent men are married. In spite of the important role of their wives in the family, the problems of this group have not been investigated yet. This study aimed to determine their problems. According to the opinion of these women social problems are the most important. Therefore this paper discusses their social problems in order to assess necessary social supports. Method: A qualitative study was designed based on focus group discussions (FGD) and in depth interviews. A total of 20 addict men from two age categories, 33 addict men’s wives from three age and education categories and several therapists selected from a referral drug abuse treatment center in the eastern district of Tehran. Information was collected based on open questions. These categories included social aspects, social and interpersonal relationships, satisfaction with the relationships and family security. Findings: Four categories of social problems were found in the 6 FGD and 15 in depth interviews. These categories included social aspects, social and interpersonal relationships, satisfaction with the relationships and family security. Social rejecting and labeling were expressed by most of the interviewed persons. Most of them declared that their relationships had been limited. In most meetings women took part without their husbands and their relationships were restricted to persons who were accepted by the addict husband, such as other addicts and drug dealers. On the other hands, the family security has been threatened by the addict husband, neighbors and other people in society. At the same time, most husbands were not aware about such problems. Results: Wives of addict men are one of the disadvantaged groups of the society. Destigmatization of the families, involving the families in self help groups and providing needed social services are recommended.