Introduction: We need a different approach for prevention of social problems such as addiction in university students. Medical students need more attention because they are more familiar with some of the drugs. This study aimed to develop a model for this group.

Method: Along with an extensive literature review, we developed a preliminary model and used Delphi method to validate it. We collected comments of 30 social problems experts, who have good experiences in the field of prevention of substance abuse in students, by email from April 2014 to August 2015 during three rounds of Delphi study.

Finding: For the prevention of addiction and other social problems among the students we must consider these principles: Emphasis on quality of life, active participation of the students in the prevention programs, and considering cultural differences in planning. These are main principles in this approach.

Discussion: Using opinions of a wide range of experts on prevention of addiction, using participatory approaches to cover the weaknesses of previous models are the most important strengths of this model.