Introduction : The purpose of this study was to examine some factors associated with adolescent substance abuse, by using the theory of planned behavior ( TPB ) framework.

  Methods: This study has been a cross sectional one. A measure consisting of TPB constructs was developed and administered to a sample of adolescents in Tehran, Iran. Data was analyzed to assess the association between TPB constructs and demographic variables and behavioral intention.

  Finding: Totally, 433 male students aged between 11 and 19 were studied. The analysis has shown that drug abuse behavioral intention was predicted by TPB constructs ( attitude, subjective norm but no perceived behavioral control) and tobacco use. Behavioral intention was associated with mother`s education grade and exited the tobacco and substance user among family members and friends too.

  Conclusion: Findings have indicated that substance abuse might be predicted by TPB constructs and associated by some demographic variables.